The availability of SARS-nCoV-2 genomes from across the globe provides a unique opportunity to understand the impact of genetic variants and their impact on diagnostics, apart from understanding the genetic epidemiology of the pathogen.
A systematic approach to compile the genomes available in public domain has been initiated as part of the COVID-19 Genomepedia Initiative. In tandem, a systematic approach has been employed to analyse the genetic variants from the genomes publicly available.
The COVID-19 Genome Watchpost is an initiative at the Vinod Scaria Lab at the CSIR Institute of Genomics and Integrative Biology (CSIR-IGIB), Delhi to make available up-to-date information on genome analyses of the SARS-nCoV-2 genomes. The initiative aims to understand the genomic variants and their impact on diagnostics, therapeutics and potential vaccines for COVID-19
One of the obvious questions to ask, is whether the genetic variants could possibly impact the diagnostic efficiencies of Nucleic Acid Tests for COVID-19. To this end, the compilation of primer and probe sequences for diagnosis of COVID-19 using Realtime PCR tests, created by volunteers contributing through a focussed crowsdourcing approach was used.
The initial analysis reveals, that the primer / probe sites for the N gene have a high frequency of variants in global genomes of SARS-nCoV-2 with potential detrimental effect on diagnostic efficiencies.
A systematic approach to compile the genomes available in public domain has been initiated as part of the COVID-19 Genomepedia Initiative. In tandem, a systematic approach has been employed to analyse the genetic variants from the genomes publicly available.
The COVID-19 Genome Watchpost is an initiative at the Vinod Scaria Lab at the CSIR Institute of Genomics and Integrative Biology (CSIR-IGIB), Delhi to make available up-to-date information on genome analyses of the SARS-nCoV-2 genomes. The initiative aims to understand the genomic variants and their impact on diagnostics, therapeutics and potential vaccines for COVID-19
One of the obvious questions to ask, is whether the genetic variants could possibly impact the diagnostic efficiencies of Nucleic Acid Tests for COVID-19. To this end, the compilation of primer and probe sequences for diagnosis of COVID-19 using Realtime PCR tests, created by volunteers contributing through a focussed crowsdourcing approach was used.
The initial analysis reveals, that the primer / probe sites for the N gene have a high frequency of variants in global genomes of SARS-nCoV-2 with potential detrimental effect on diagnostic efficiencies.
More on this analysis and the methodology employed is detailed in the recent update of COVID-19 Genome Watchpost.
What is the weakest part of the COVID-19 LIFE CYCLE, can it's cycle be intrerupted or killed during the life cycle
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